Mini‒review: clinical and molecular markers in early diabetic nephropathy
نویسندگان
چکیده
منابع مشابه
Urinary Markers of Tubular Injury in Early Diabetic Nephropathy
Diabetic nephropathy (DN) is a common and serious complication of diabetes associated with adverse outcomes of renal failure, cardiovascular disease, and premature mortality. Early and accurate identification of DN is therefore of critical importance to improve patient outcomes. Albuminuria, a marker of glomerular involvement in early renal damage, cannot always detect early DN. Thus, more sens...
متن کاملEarly Diabetic Nephropathy
OBJECTIVE Diabetic nephropathy (DN) is a major cause of mortality in type 1 diabetes. Reduced insulin sensitivity is a well-documented component of type 1 diabetes. We hypothesized that baseline insulin sensitivity would predict development of DN over 6 years. RESEARCH DESIGN AND METHODS We assessed the relationship between insulin sensitivity at baseline and development of early phenotypes o...
متن کاملMINIREVIEW Diabetic Nephropathy: Mechanisms of Renal Disease Progression
Diabetic Nephropathy: Mechanisms of Renal Disease Progression YASHPAL S. KANWAR,* JUN WADA, LIN SUN,* PING XIE,* ELISABETH I. WALLNER, SHELDON CHEN, SUMANT CHUGH, AND FARHAD R. DANESH *Department of Pathology, Northwestern University School of Medicine, Chicago, Illinois 60611; Department of Medicine, Okayama University School of Medicine, Okayama, 700-8558 Japan; and Department of Medicine, No...
متن کاملDiabetic nephropathy. Prevention and early referral.
OBJECTIVE To review the clinical and pathophysiologic features of diabetic nephropathy and to examine evidence supporting primary, secondary, and tertiary treatment strategies. QUALITY OF EVIDENCE The medical literature provides both level 1 and level 2 evidence on treatment of diabetic nephropathy, including randomized controlled trials, well-designed clinical trials without randomization, c...
متن کاملEarly signs of diabetic nephropathy in childhood
337 ISSN 1758-1907 10.2217/DMT.12.37 © 2012 Future Medicine Ltd Diabetes Manage. (2012) 2(4), 337–353 Summary Diabetes represents the single largest cause of end-stage kidney failure in adults. Although diabetic nephropathy is an uncommon cause of kidney failure during childhood, there is clear evidence that the underlying events increase to progressive kidney injury begin during childhood and ...
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ژورنال
عنوان ژورنال: MOJ Drug Design Development & Therapy
سال: 2018
ISSN: 2575-9094
DOI: 10.15406/mojddt.2018.02.00034